Categories: N-N Bond Formation >
Synthesis of Hydrazines
The electrophilic amination of primary aliphatic and aromatic amines with a diethylketomalonate-derived oxaziridine affords the corresponding N-Boc hydrazines in good to excellent yields. The method allows a one-pot synthesis of pyrazoles from primary amines.
A. Armstrong, L. H. Jones, J. D. Knight, R. D. Kelsey, Org. Lett., 2005, 7, 713-716.