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Synthesis of nitrones


Recent Literature

A general, high yielding, and user and environmentally friendly catalytic oxidation procedure for the chemoselective oxidation of imines to nitrones is reported.
G. Soldaini, F. Cardona, A. Goti, Org. Lett., 2007, 9, 473-476.

A general, efficient and metal-free protocol for the direct oxidation of secondary amines to nitrones tolerates other functional groups or existing stereogenic centers using Oxone in a biphasic basic medium as the sole oxidant.
C. Gella, È. Ferrer, R. Alibés, F. Busqué, P. de March, M. Figueredo, J. Font, J. Org. Chem., 2009, 74, 6365-6367.

A catalyst-free oxidation of benzylic secondary amines using H2O2 in MeOH or CH2CN provides a selective access to a variety of C-aryl nitrones in good yields.
A. S. Granato, G. W. Amarante, J. Adrio, J. Org. Chem., 2021, 86, 13817-13823.

Oxidations of organic substrates such as sulfides, secondary amines, N-hydroxylamines, and tertiary amines with molecular oxygen in the presence of 5-ethyl-3-methyllumiflavinium perchlorate catalyst and hydrazine monohydrate in 2,2,2-trifluoroethanol occur highly efficiently to give the corresponding oxidized compounds in excellent yields.
Y. Imada, H. Iida, S. Ono, S.-I. Murahashi, J. Am. Chem. Soc., 2003, 125, 2868-2869.