Categories: N-O Bond Formation >
Synthesis of nitrones
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Recent Literature
A general, high yielding, and user and environmentally friendly catalytic
oxidation procedure for the chemoselective oxidation of imines to nitrones is
reported.
G. Soldaini, F. Cardona, A. Goti, Org. Lett., 2007,
9, 473-476.
A general, efficient and metal-free protocol for the direct oxidation of
secondary amines to nitrones tolerates other functional groups or existing
stereogenic centers using Oxone in a biphasic basic medium as the sole oxidant.
C. Gella, È. Ferrer, R. Alibés, F. Busqué, P. de March, M. Figueredo, J. Font, J. Org. Chem., 2009,
74, 6365-6367.
A catalyst-free oxidation of benzylic secondary amines using H2O2
in MeOH or CH2CN provides a selective access to a variety of C-aryl
nitrones in good yields.
A. S. Granato, G. W. Amarante, J. Adrio, J. Org. Chem., 2021, 86,
13817-13823.
Oxidations of organic substrates such as sulfides, secondary amines, N-hydroxylamines,
and tertiary amines with molecular oxygen in the presence of
5-ethyl-3-methyllumiflavinium perchlorate catalyst and hydrazine monohydrate
in 2,2,2-trifluoroethanol occur highly efficiently to give the corresponding
oxidized compounds in excellent yields.
Y. Imada, H. Iida, S. Ono, S.-I. Murahashi, J. Am. Chem. Soc., 2003, 125, 2868-2869.