Categories: N-S Bond Formation >
Synthesis of Sulfamoyl Fluorides
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Recent Literature
Access to SuFExable compounds was remarkably simplified using the solid FO2S-donor
SuFEx-IT. A hectogram-scale and SO2F2-free preparation of
the analogous desmethyl SuFEx-IT from inexpensive starting materials in high
yield and without chromatographic purification is possible. The use of this
reagent enables the preparation of a series of fluorosulfates and sulfamoyl
fluorides in very high yields.
J. Bertram, F. Neumaier, B. D. Zlatopolskiy, B. Neumaier, J. Org. Chem., 2024, 89,
3821-3833.