Categories: O-B Bond Formation >
Synthesis of boronic acids
Recent Literature
The deprotection of boronic esters can be performed under mild conditions in the
presence of methylboronic acid. The reaction provides high yields, and
eliminates cumbersome and problematic purification steps due to the high
volatility of methylboronic acid and its diol esters.
S. P. A. Hinkes, C. D. P. Klein,
Org. Lett., 2019, 21, 3048-3052.
A catalytic system has been optimized to promote hydrolysis of trifluoroborates
and formation of boronates from boronic acids. FeCl3 associated with imidazole and water favors boron
refunctionalization under mild conditions.
J. L. Wood, L. D. Marciasini, M. Vaultier, M. Pucheault, Synlett, 2014, 25,
551-555.