Categories: O-H Bond Formation >
1,2-Reduction of α,β-unsaturated compounds
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Recent Literature
An on-water Ir(III)-diamine catalysis represents an efficient, simple and
environmentally friendly catalytic system for the transfer hydrogenation of
aldehydes. The catalyst tolerates various synthetically useful groups
including nitro groups, halogens, ketones, esters and olefins.
X. Wu, J. Liu, X. Li, A. Zanotti-Gerosa, F. Hancock, D. Vinci, J. Ruan, J.
Xiao, Angew. Chem. Int. Ed., 2006, 45, 6717-6722.
[Cp*Ir(2,2′-bpyO)(H2O)] is a highly efficient and general catalyst
for transfer hydrogenation of carbonyl compounds and chemoselective transfer
hydrogenation of unsaturated aldehydes with isopropanol under neutral conditions.
The reaction tolerates deducible groups such as nitro, cyano, ester, and halide.
R. Wang, Y. Tang, M. Xu, C. Meng, F. Li, J. Org. Chem., 2018, 83,
2274-2281.
Chemoselective Luche-Type Reduction of α,β-Unsaturated Ketones by Magnesium
Catalysis
Y. K. Jang, M. Magre, M. Rueping,
Org. Lett., 2019, 21, 8349-8352.
Asymmetric ligand-accelerated catalysis by copper hydride allows the synthesis
of valued nonracemic allylic alcohols in very good yields.
R. Moser, Ž. V. Bošković, C. S. Crowe, B. H. Lipshutz, J. Am. Chem. Soc., 2010,
132, 7852-7853.
A highly efficient asymmetric hydrogenation of α-substituted α,β-unsaturated
acyclic ketones in the presence of chiral spiro iridium complexes provides
chiral 2-substituted allylic alcohols and a concise route to (-)-mesembrine.
Q.-Q. Zhang, J.-H. Xie, X.-H. Yang, J.-B. Xie, Q.-L. Zhou, Org. Lett., 2012,
14, 6158-6161.