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P=N Bond Formation

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FeCl2 catalyzes a facile imidization of phosphines with N-acyloxyamides to provide synthetically useful N-acyliminophosphoranes with high functional group tolerance. The transformation can be scaled up to gram scale with a catalyst loading of 1 mol%. The iminophosphoranyl moiety is an effective directing group for Rh(III)-catalyzed ortho C(sp2)-H bond amidations.
S. Lin, B. Lin, Z. Zhang, J. Chen, Y. Luo, Y. Xia, Org. Lett., 2022, 24, 3302-3306.