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Synthesis of Tetrasulfides

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The use of a six-membered thiamine disulfurating reagent enables a mild and efficient moduling disulfuration for polysulfide construction. Under the control of energy release of ring strain, diverse unsymmetrical trisulfides and tetrasulfides were generated through the assembly of nucleophiles on both sides of the sulfur-sulfur motif.
J. Xue, X. Jiang, Org. Lett., 2020, 22, 8044–8048.