Categories: Synthesis of N-Heterocycles, Synthesis of O-Heterocycles >
Synthesis of 1,2,5-oxadiazoles
1,1'-Carbonyldiimidazole induces the formation of various 3,4-disubstituted 1,2,5-oxadiazoles (furazans) from the corresponding bisoximes at ambient temperature. This method enables the prepartion of these inherently energetic compounds at temperatures well below their decomposition points and with improved functional group compatibility.
A. J. Neel, R. Zhao, Org. Lett., 2018, 20, 2024-2027.