Organic Chemistry Portal >
Reactions > Organic Synthesis Search

Categories: Synthesis of N-Heterocycles >

Synthesis of 2H-pyrroles

Recent Literature


N-Benzyl ketimines undergo [3 + 2] cycloaddition with arylacetylenes in KOtBu/DMSO solution to provide 2,3,5-triarylpyrrolines in good yields. A subsequent in situ oxidation with chloranil or DDQ gives 2,3,5-triaryl-2H-pyrroles in good yields.
I. A. Bidusenko, E. Y. Schmidt, I. A. Ushakov, A. V. Vashchenko, B. A. Trofimov, Org. Lett., 2021, 23, 4121-4126.