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Categories: Synthesis of N-Heterocycles > Lactams

Synthesis of 3,6-dihydro-2-pyridinones

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A palladium-catalyzed carbonylative [5+1] cycloaddition of N-tosyl vinylaziridines with CO provides α,β-unsaturated δ-lactams in dimethylformamide and β,γ-unsaturated δ-lactams in tetrahydrofuran in very good yields.
T. Zhang, S. Wang, D. Zuo, J. Zhao, W. Luo, C. Wang, P. Li, J. Org. Chem., 2022, 87, 10372-10376.