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Synthesis of 3-isoxazolines

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The use of tetrabutylammonium fluoride (TBAF) enables a versatile approach to isoxazolines and pyrazolines by the cyclization of alkyne substrates under mild reaction conditions. A deprotection/functionalization method is described, leading to a substituted pyrazoline in good diastereoselectivity.
E. Nagy, S. D. Lepore, Org. Lett., 2017, 19, 3695-3698.