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Synthesis of 3-pyrazolines
Recent Literature
A catalytic asymmetric 1,3-dipolar cycloaddition of terminal alkynes with
acyclic azomethine imines generated in situ from the corresponding aldehydes and
hydrazides was realized using Cu(I)/pybox and axially chiral dicarboxylic acid
cocatalysts.
T. Hashimoto, Y. Takiguchi, K. Maruoka, J. Am. Chem. Soc., 2013,
135, 11473-11476.
The use of tetrabutylammonium fluoride (TBAF) enables a versatile approach to
isoxazolines and pyrazolines by the cyclization of alkyne substrates under mild
reaction conditions. A deprotection/functionalization method is described,
leading to a substituted pyrazoline in good diastereoselectivity.
E. Nagy, S. D. Lepore, Org. Lett.,
2017, 19, 3695-3698.