Categories: Synthesis of N-Heterocycles >
Synthesis of 4-imidazolidinones
Recent Literature
A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi
three-component reaction products rapidly affords imidazolidinones. This
oxidative radical cyclization generates highly decorated privileged heterocycles.
K. Schofield, C. Foley, C. Hulme, Org. Lett., 2021, 23,
107-112.
A diastereo- and enantioselective (3 + 2) cycloaddition between
5-vinyloxazolidine-2,4-diones (VOxD) and electrophilic imines under palladium
catalysis provides 4-imidazolidinones in good yields.
A. Roblin, N. Casaretto, A. Archambeau, Org. Lett., 2023, 25,
6453-6458.
A mild one-pot synthesis of highly functionalized
imidazolidines and oxazolidines via SN2-type ring-opening of
activated aziridines and epoxides with amines followed by p-toluenesulfonic acid catalyzed intramolecular cyclization with
aldehydes tolerates a variety of functional groups and furnishes the
desired products in high yields with excellent stereoselectivities.
S. Tarannum, S. Sk, S. Das, I. A. Wani, M. K. Ghorai, J. Org. Chem., 2020, 85,
367-379.