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Synthesis of 4-pyridones

Recent Literature

Supported Au nanoparticles on TiO2 catalyze the hydration/6-endo cyclization of skipped diynones to γ-pyrones in aqueous dioxane, via triple bond activation. If aqueous methylamine is added, N-methyl-4-pyridones are exclusively formed good yields via an analogous hydroamination/Au-catalyzed 6-endo cyclization pathway.
E.-M. Zantioti-Chatzouda, V. Kotzabasaki, M. Stratakis, J. Org. Chem., 2022, 87, 8525-8533.