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Synthesis of 1,2,3-triazolo[1,5-a]pyridines

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A heterogeneous copper(II)-catalyzed oxidative cyclization of 2-pyridine ketone hydrazones was achieved in ethyl acetate at room temperature in the presence of an MCM-41-anchored bidentate 2-aminoethylamino copper(II) catalyst and air as the oxidant to provide various [1,2,3]triazolo[1,5-a]pyridines in good yields. The catalyst can be recovered by filtration and reused at least seven times.
G. Jiang, Y. Lin, M. Cai, H. Zhao, Synthesis, 2019, 51, 4487-4497.


A heterogeneous copper(II)-catalyzed oxidative cyclization of 2-pyridine ketone hydrazones was achieved in ethyl acetate at room temperature in the presence of an MCM-41-anchored bidentate 2-aminoethylamino copper(II) catalyst and air as the oxidant to provide various [1,2,3]triazolo[1,5-a]pyridines in good yields. The catalyst can be recovered by filtration and reused at least seven times.
G. Jiang, Y. Lin, M. Cai, H. Zhao, Synthesis, 2019, 51, 4487-4497.