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Synthesis of 2-Benzoxazinones (2H-1,4-Benzoxazin-2-ones)

Recent Literature


A transition-metal-free alkylation and acylation of C(sp2)-H bonds in biologically relevant 2-benzoxazinones with 1,4-dihydropyridines offers excellent functional group compatibility and a broad substrate scope.
Y. Byun, J. Moon, W. An, N. K. Mishra, H. S. Kim, P. Ghosh, I. S. Kim, J. Org. Chem., 2021, 86, 12247-12256.


Efficient reactions of α-keto acids with 2-aminobenzamides, 2-aminobenzenethiols, benzene-1,2-diamines, and 2-aminophenols provide quinazolinones, benzothiazoles, quinoxalinones, and benzoxazinones under catalyst-free conditions, using water as the solvent. Products can be easily purified through filtration and washing with ethanol (or crystallized).
J. Huang, W. Chen, J. Liang, Q. Yan, Y. Fan, M.-W. Chen, Y. Peng, J. Org. Chem., 2021, 86, 14866-14882.