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Synthesis of acridones

Recent Literature


A Pd-catalyzed dual C-H carbonylation of commercially available diarylamines using Co2(CO)8 as a safe CO source provides diversified acridones in good yields. The protocol features good functional group compatibility, operational safety, easy scale-up, and versatile transformations.
J. Huang, W. Guo, W. Wu, F. Yin, H. Wang, C. Tao, H. Zhou, W. Hu, J. Org. Chem., 2024, 89, 2014-2023.


tert-Butyl hydroperoxide promotes an oxidative annulation reaction of isatins with 2-(trimethylsilyl)aryl triflates for the convenient synthesis of acridone derivatives. The reaction may proceed via consecutive Baeyer-Villiger-type rearrangement followed by an intermolecular cyclization. This convenient method offers broad substrate scope and good functional group tolerance.
M. Luo, N. Dong, M. Zhu, Y. Wang, C. Xu, G. Yin, J. Org. Chem., 2023, 88, 9419-9423.