Categories: Synthesis of N-Heterocycles > benzo-fused N-Heterocycles >
Synthesis of acridones
Recent Literature
A Pd-catalyzed dual C-H carbonylation of commercially available diarylamines
using Co2(CO)8 as a safe CO source provides diversified acridones
in good yields.
The protocol features good functional group compatibility, operational safety,
easy scale-up, and versatile transformations.
J. Huang, W. Guo, W. Wu, F. Yin, H. Wang, C. Tao, H. Zhou, W. Hu, J. Org. Chem., 2024, 89,
2014-2023.
tert-Butyl hydroperoxide promotes an oxidative annulation reaction of
isatins with 2-(trimethylsilyl)aryl triflates for the convenient synthesis of
acridone derivatives. The reaction may proceed via consecutive
Baeyer-Villiger-type rearrangement followed by an intermolecular cyclization.
This convenient method offers broad substrate scope and good functional group
tolerance.
M. Luo, N. Dong, M. Zhu, Y. Wang, C. Xu, G. Yin, J. Org. Chem., 2023, 88,
9419-9423.