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Synthesis of Benzofuran-3(2H)-ones

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An asymmetric dual-metal relay catalysis strategy that combines Rh/chiral sulfur-olefin-catalyzed enantioselective 1,2-addition with a Pd-catalyzed intramolecular C-O coupling enables a rapid and efficient synthesis of quaternary carbon-containing gem-diaryl benzofuran-3(2H)-ones in good yields in a highly enantioselective manner.
Z.-F. Zhang, D.-X. Zhu, W.-W. Chen, B. Xu, M.-H. Xu, Org. Lett., 2017, 19, 2726-2729.


An N-Heterocyclic carbene efficiently catalyzed an intramolecular nucleophilic substitution reaction to yield benzopyrones and benzofuranones depending on the substitution pattern.
J. He, J. Zheng, J. Liu, X. She, X. Pan, Org. Lett., 2006, 8, 4637-4640.