Categories: Synthesis of N-Heterocycles, Synthesis of S-Heterocycles > benzo-fused N-Heterocycles, benzo-fused S-Heterocycles >
Synthesis of benzoisothiazol-3-ones
Recent Literature
In a copper-catalyzed synthesis of benzo[d]isothiazol-3(2H)-ones
and N-acyl-benzothiazetidine by intramolecular dehydrogenative
cyclization, a new nitrogen-sulfur bond is formed by N-H/S-H coupling. The
present reaction tolerates various functional groups and gives products in gram
scale.
Z. Wang, Y. Kuninobu, M. Kanai, J. Org. Chem., 2013,
78, 7337-7342.
While an N-S bond coupling/oxidation cascade of N-(2-mercaptophenyl)-N'-substituted
ureas provides benzothiadiazin-3-one 1-oxides; the transformation of
2-mercaptobenzamides only occurs via N-S bond coupling to access
benzisothiazol-3-ones in good yields. The photochemical syntheses offer mild
conditions, excellent chemoselectivity, and functional group compatibility.
H. Li, Z. Xiong, S. Sheng, J. Chen, J. Org. Chem., 2023, 88,
16949-16959.