Categories: Synthesis of N-Heterocycles > benzo-fused N-Heterocycles >

Synthesis of isoindolines

Recent Literature

A facile method provides N-aryl-substituted azacycles from arylamines and cyclic ethers in the presence of POCl₃ and DBU. Using this method, various azacycloalkanes, isoindolines, and tetrahydroisoquinolines were prepared in high yields. This synthetic method offers an efficient approach to the production of five- and six-membered azacycles.
M. T. La, S. Kang, H.-K. Kim, J. Org. Chem., 2019, 84, 6689-6696.

Acid-catalysed intramolecular hydroamination of 2-alkenylarylethylamine derivatives gives smoothly isoindolines via benzylic carbenium ion generation.
L. Henderson, D. W. Knight, A. C. Williams, Synlett, 2012, 23, 1667-1669.

Synergistic palladium and Brønsted acid catalysis enables a diastereoselective cyclization of chiral sulfinamides as nucleophiles to provide chiral isoindolines with good yields and high diastereoselectivities.
C.-T. Hung, C.-W. Lu, S.-H. Huang, Y.-F. Lu, H.-C. Chou, C.-C. Tsai, J. Org. Chem., 2021, 86, 12354-12366.