Categories: Synthesis of N-Heterocycles > benzo-fused N-Heterocycles >
Synthesis of isoquinoline-1,3(2H,4H)-diones
Recent Literature
A Pd-catalyzed and photoinduced benzylic C-H carbonylation/annulation
reaction of O-benzyl hydroxylamides provides homophthalimides under mild
conditions. The use of a catalytic amount of base is crucial for the reaction to
achieve high yields. A Pd-catalyzed generation of an amidyl radical and 1,5-HAT
to give a benzylic radical is followed by carbonylation and annulation.
W.-W. Ding, Y. Zhou, S. Song, Z.-Y. Han, Org. Lett.,
2022, 24, 7350-7354.
A palladium-catalyzed cross-coupling reaction of aryl halides with
isoquinoline-1,3(2H,4H)-diones enables the synthesis of 4-aryl
isoquinoline-1,3(2H,4H)-diones. The products could be conveniently
transformed to 4-aryl tetrahydroisoquinolines.
Y. Yang, Y. Li, C. Cheng, G. Yang, J. Zhang, Y. Zhang, Y. Zhao, L. Zhang, C. Li,
L. Tang, J. Org. Chem., 2018, 83,
3348-3353..