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Synthesis of isoquinoline-1,3(2H,4H)-diones

Recent Literature


A Pd-catalyzed and photoinduced benzylic C-H carbonylation/annulation reaction of O-benzyl hydroxylamides provides homophthalimides under mild conditions. The use of a catalytic amount of base is crucial for the reaction to achieve high yields. A Pd-catalyzed generation of an amidyl radical and 1,5-HAT to give a benzylic radical is followed by carbonylation and annulation.
W.-W. Ding, Y. Zhou, S. Song, Z.-Y. Han, Org. Lett., 2022, 24, 7350-7354.


A palladium-catalyzed cross-coupling reaction of aryl halides with isoquinoline-1,3(2H,4H)-diones enables the synthesis of 4-aryl isoquinoline-1,3(2H,4H)-diones. The products could be conveniently transformed to 4-aryl tetrahydroisoquinolines.
Y. Yang, Y. Li, C. Cheng, G. Yang, J. Zhang, Y. Zhang, Y. Zhao, L. Zhang, C. Li, L. Tang, J. Org. Chem., 2018, 83, 3348-3353..