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Synthesis of phenanthridinones

Recent Literature


Visible light and KOtBu promote a dehydrogenative C-H carbonylative lactamization of 2-arylanilines with DMF as the sole carbonyl source. The irreversible release of hydrogen gas drags this reaction to the stable phenanthridinone products.
Y.-Z. Chen, T.-H. Ding, Q.-Q. Li, J.-P. Qu, Y.-B. Kang, Org. Lett., 2023, 25, 2612-2615.


In a constant-potential electrolysis (CPE) for the synthesis of phenanthridinones, TBAI plays a dual role as both a redox catalyst and a supporting electrolyte. This metal and oxidant free reaction proceeds with 100% current efficiency via an intramolecular C-H activation under mild reaction conditions and with a short reaction time.
K. Subramanian, S. L. Yedage, K. Sethi, B. M. Bhanage, Synlett, 2021, 32, 999-1003.