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Synthesis of phthalazines

Recent Literature

A one-pot strategy allows the synthesis of phthalazines and pyridazino-aromatics starting from aromatic aldehydes. A variety of substituents ranging from electron withdrawing to donating is tolerated furnishing the desired 1,2-diazine in good to excellent yields. A subsequent bidentate Lewis acid catalyzed inverse electron-demand Diels-Alder (IEDDA) reaction opens a novel two-step entry into substituted naphthalenes, such as Naproxen.
S. N. Kessler, H. A. Wegner, Org. Lett., 2012, 14, 3268-3271.