Categories: Synthesis of N-Heterocycles > benzo-fused N-Heterocycles
Synthesis of phthalazines
Recent Literature
A one-pot strategy allows the synthesis of phthalazines and pyridazino-aromatics
starting from aromatic aldehydes. A variety of substituents ranging from
electron withdrawing to donating is tolerated furnishing the desired 1,2-diazine
in good to excellent yields. A subsequent bidentate Lewis acid catalyzed inverse
electron-demand Diels-Alder (IEDDA) reaction opens a novel two-step entry into
substituted naphthalenes, such as Naproxen.
S. N. Kessler, H. A. Wegner, Org. Lett., 2012,
14, 3268-3271.
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