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Synthesis of tetrahydroquinazolines

Recent Literature

An iridium-catalyzed asymmetric [4 + 2] cycloaddition of 1,3,5-triazinanes with 2-(1-hydroxyallyl)anilines/2-(1-hydroxyallyl)phenols provides a wide range of tetrahydroquinazolines in good yields and excellent enantioselectivities. In addition, chiral 1,3-benzoxazines, which are challenging products, could also be obtained in excellent enantioselectivities using this protocol.
S. Tang, Z. Cheng, P. Zhang, Y. Shao, J. Sun, Org. Lett., 2023, 25, 3639-3643.

A copper-catalyzed asymmetric formal [4 + 2]-cycloaddition of copper-allenylidenes and hexahydro-1,3,5-triazines provides chiral tetrahydroquinazolines in good yields and with high enantioselectivities for most cases.
D. Ji, C. Wang, J. Sun, Org. Lett., 2018, 20, 3710-3713.