Categories: Synthesis of N-Heterocycles > benzo-fused N-Heterocycles >
Synthesis of tetrahydroquinoxalines
Recent Literature
The use of HBpin as a hydrogen source enables a metal-free environmentally
benign, simple, and efficient transfer hydrogenation process of quinoxalines to
provide the desired tetrahydroquinoxalines in good yields in the presence of Bu4NBr
as a noncorrosive and low-cost catalyst.
Q. Guo, J. Chen, G. Shen, G. Lu, X. Yang, Y. Tang, Y. Zhu, S. Wu, B. Fan, J. Org. Chem., 2022, 87,
540-546.
SN2-type ring-opening of activated aziridines with 2-bromoanilines
followed by a Pd-catalyzed intramolecular C-N bond formation enable a highly
regio- and stereoselective route for the synthesis of racemic and nonracemic
tetrahydroquinoxalines.
M. K. Ghorai, A. K. Sahoo, S. Kumar, Org. Lett., 2011,
13, 5972-5975.