Categories: Synthesis of S-Heterocycles, C-S Bond Formation >
Synthesis of cyclic sulfides
| Synthesis of | |||
| Thiiranes |
 |
Tetrahydrothiophenes |  |
| Tetrahydrothiopyrans |
 |
Thiomorpholines |  |
Recent Literature
With CuI as the catalyst and K3PO4 • 3 H2O as
the base, a highly efficient, ligand-free intramolecular S-vinylation of thiols
with vinyl chlorides or bromides was successfully implemented. Moreover,
competition experiments revealed that the 4-exo cyclization is
fundamentally preferred over other modes (5-exo, 6-exo, and 6-endo)
of cyclization.
Q. Zhao, L. Li, Y. Fang, D. Sun, C. Li, J. Org. Chem., 2009,
74, 459-462.