Categories: Synthesis of N-Heterocycles >
Synthesis of imidazol-5-ones
A simple and efficient approach to 4-arylidene-2-alkyl-4,5-dihydro-1H-imidazol-5-ones (2,4-disubstituted imidazolones) uses readily available 2-bromo-3-alkylacrylic acids and amidines as the starting materials without addition of any ligand or additive. The reaction is performed under mild conditions and will be of wide application in organic chemistry and medicinal chemistry.
X. Gong, H. Yang, H. Liu, Y. Jiang, Y. Zaho, H. Fu, Org. Lett., 2010, 12, 3128-3131.