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Synthesis of oxetenes

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A dicationic (S)-BINAP-Pd catalyst enables a highly enantioselective and atom-economical [2 + 2] cycloaddition of various alkynes with trifluoropyruvate to yield oxetene derivatives, which can serve as novel chiral building blocks for pharmaceuticals and agrochemicals and can also be transformed into a variety of enantiomerically enriched CF3-substituted compounds.
K. Aikawa, Y. Hioki, N. Shimizu, K. Mikami, J. Am. Chem. Soc., 2011, 133, 20092-20095.