Categories: Synthesis of N-Heterocycles >
Synthesis of pyrazines
Recent Literature
[Cp*IrCl2]2 catalyzes a C-alkylation of a methyl group
on N-heteroaromatic compounds, including pyridines, pyrimidines,
pyrazines, quinolines, quinoxalines, and isoquinolines, with alcohols in the
presence of potassium t-butoxide and 18-crown-6-ether.
M. Onoda, K.-i. Fujita,
Org. Lett., 2020, 22, 7230-7233.
The reactivity of α-imino carbenoids derived from α-diazo oxime ethers with 2H-azirines
enables a synthesis of unsymmetrically substituted pyrazines. The reaction
provides highly substituted pyrazines in good to excellent yields.
N. S. Y. Loy, S. Kim, C.-M. Park, Org. Lett.,
2015,
17, 395-397.
The combination of Pd/PTABS enables an exceptionally mild and highly efficient
catalytic amination of chloroheteroarenes with secondary amines at ambient
temperature.
S. S. M. Bandaru, S. Bhilare, N. Chrysochos, V. Gayakhe, I. Trentin, C. Schulzke,
A. R. Kapdi, Org. Lett.,
2018, 20, 473-476.