Categories: Synthesis of O-Heterocycles >
Synthesis of 4H-pyrans
Recent Literature
An NHC-catalyzed [2 + 4] cyclization of alkynyl ester with α,β-unsaturated
ketone provides highly substituted 4H-pyran derivatives in gooy yields.
This strategy offers cheap and easily
available starting materials, mild reaction conditions, and high atom economy.
F. Lu, Y. Chen, X. Song, C. Yu, T. Li, K. Zhang, C. Yao, J. Org. Chem., 2022, 87,
6902-6909.
Inexpensive and commercially available nano-powder magnetite or iron(III) oxide
can be used as catalyst in a new, straightforward, and fast protocol for the
construction of 4-substituted-4H-pyrans. The reaction implies a tandem
process, involving an aldol condensation, a Michael-type addition, and a
dehydrating annulation.
R. Cano, D. J. Ramón, M. Yus, Synlett, 2011,
2017-2019.