Categories: Synthesis of N-Heterocycles >
Synthesis of pyrazines
The reactivity of α-imino carbenoids derived from α-diazo oxime ethers with 2H-azirines enables a synthesis of unsymmetrically substituted pyrazines. The reaction provides highly substituted pyrazines in good to excellent yields.
N. S. Y. Loy, S. Kim, C.-M. Park, Org. Lett., 2015, 17, 395-397.
The combination of Pd/PTABS enables an exceptionally mild and highly efficient catalytic amination of chloroheteroarenes with secondary amines at ambient temperature.
S. S. M. Bandaru, S. Bhilare, N. Chrysochos, V. Gayakhe, I. Trentin, C. Schulzke, A. R. Kapdi, Org. Lett., 2018, 20, 473-476.