Categories: Synthesis of S-Heterocycles, C-S Bond Formation > Synthesis of Cyclic Sulfides >
Synthesis of tetrahydrothiopyrans
Tetrahydrothiopyrans have been efficiently synthesized in good yields with excellent diastereoselectivity from aldehydes and substituted 5-methylhex-4-ene-1-thiol via (3,5)-thionium-ene cyclization reaction mediated by boron trifluoride etherate.
S. Bondalapati, P. Gogoi, K. Indukuri, A. K. Saikia, J. Org. Chem., 2012, 77, 2508-2512.