Categories: Synthesis of N-Heterocycles, Synthesis of S-Heterocycles >
Synthesis of thiazolines
Recent Literature
N-(ω-Bromoalkyl)dichlorothiophosphoramidates enable a single-reagent-driven
multistep preparation of a wide range of 2-substituted thiazolines and
1,3-thiazines from aldoximes, nitriles, or carboxylic acids.
S. Battacharyya, U. Pathak,
Synthesis, 2015, 47, 3553-3560.
A mild reaction of α,α-difluoroalkyl amines with β-amino alcohols, β-amino thiols, and β-diamines
affords the
corresponding oxazoline, thiazoline, and imidazoline derivatives, respectively. The
conditions are
applicable for the synthesis of optically active heterocyclic compounds.
T. Fukuhara, C. Hasegawa, S. Hara, Synthesis, 2007,
1528-1534.
In the condensation of L-cysteine and aryl nitriles, pure (R)-2-aryl-4,5-dihydrothiazole-4-carboxylic
acids were obtained in good yields without racemization in a NaHCO3/NaOH-buffered
aqueous alcoholic medium.
O. V. Maltsev, V. Walter, M. J. Brandl, L. Hintermann, Synthesis, 2013, 45,
2763-2767.