Categories: Synthesis of S-Heterocycles >
Synthesis of thiophenes
Low catalyst loading of a bis(alkoxo)palladium complex enables an efficient phosphine-free direct C-H arylation of thiophenes at C2. The developed synthetic method couples aryl or heteroaryl bromides with thiophenes bearing electron-donating or electron-withdrawing groups and other heterocyclic moieties such as benzothiophene, benzofuran, and pyrrole with very good yields.
Y. Li, J. Wang, M. Huang, Z. Wang, Y. Wu, Y. Wu, J. Org. Chem., 2014, 79, 2890-2897.
Various readily available 1-mercapto-3-yn-2-ols 5 were conveniently converted into the corresponding thiophenes in good to high yields in MeOH as solvent in the presence of PdI2 as catalyst and KI as additive. The use of BmimBF4 as solvent enables the recycling of the catalyst.
B. Gabriele, R. Mancuso, L. Veltri, V. Maltese, G. Salerno, J. Org. Chem., 2012, 77, 9905-9909.
The interaction between elemental sulfur and NaOtBu enables a facile single-step protocol for the synthesis of thiophene derivatives from 1,3-diynes. A plausible mechanism based on EPR experiments revealed that the trisulfur radical anion acts as a key intermediate of this process.
G. Zhang, H. Yi, H. Chen, C. Bian, C. Liu, A. Lei, Org. Lett., 2014, 16, 6156-6159.
Copper-catalyzed tandem S-alkenylation of potassium sulfide with 1,4-diiodo-1,3-dienes enables an efficient synthetic approach to variously substituted thiophenes.
W. You, X. Yan, Q. Liao, C. Xi, Org. Lett., 2010, 12, 3930-3933.
A mild, metal-free and base-promoted thioannulation of Morita-Baylis-Hillman acetates of acetylenic aldehydes with potassium thioacetate to yield substituted thiophenes involves a tandem allylic substitution/deacetylative 5-exo-dig-thiocycloisomerization. The obtained products provide an entry to 4H-thieno[3,2-c]chromene and thieno[3,2-c]dihydroquinoline.
C. R. Reddy, R. R. Valleti, N. D. Reddy, J. Org. Chem., 2013, 78, 6495-6502.
An efficient one-step method for the synthesis of highly substituted thiophenes from thiomorpholides and α-haloketones was developed. The mechanism is discussed.
F. Matloubi Moghaddam, H. Zali Bionee, Tetrahedron, 2004, 60, 6085-6089.
An efficient and highly versatile microwave-assisted Paal-Knorr condensation of various 1,4-diketones gave furans, pyrroles and thiophenes in good yields. In addition, transformations of the methoxycarbonyl moiety, such as Curtius rearrangement, hydrolysis to carboxylic acid, or the conversion into amine by reaction with a primary amine in the presence of Me3Al, are described.
G. Minetto, L. F. Raveglia, A. Sega, M. Taddei, Eur. J. Org. Chem., 2005, 5277-5288.
Thionation of amides, 1,4-diketones, N-(2-oxoalkyl)amides, and N,N'-acylhydrazines with the use of a fluorous Lawesson's reagent leads to thioamides, thiophenes, 1,3-thiazoles, and 1,3,4-thiadiazoles in high yields. The isolation of the final products is achieved in most cases by a simple filtration.
Z. Kaleta, B. T Makowski, T. Soos, R. Dembinski, Org. Lett., 2006, 8, 1625-1628.
A direct iodocyclization of 1-mercapto-3-yn-2-ols derivatives enables the synthesis of 3-iodothiophenes. Various substrates were smoothly converted into the corresponding 3-iodothiophene derivatives in good yields by reaction with molecular iodine in the presence of NaHCO3 at room temperature in MeCN as the solvent.
B. Gabriele, R. Mancuso, G. Salerno, R. C. Larock, J. Org. Chem., 2012, 77, 7640-7645.
A rhodium-catalyzed transannulation reaction between 1,2,3-thiadiazoles and alkynes enables a highly efficient and regioselective synthesis of highly substituted thiophenes via intermediacy of a previously unknown Rh thiavinyl carbene.
D. Kurandina, V. Gevorgyan, Org. Lett., 2016, 18, 1804-1807.
Ynone trifluoroborate salts undergo a base-promoted condensation reaction with alkylthiols to provide thiophene trifluoroborates in high yield with complete regiocontrol.
P. Fricaro, L. Bialy, W. Czechtizky, M. Méndez, J. P. A. Harrity, Org. Lett., 2018, 20, 198-200.
Domino synthesis of tetrasubstituted thiophenes from 1,3-enynes and mercaptoacetaldehyde using DABCO at room temperature offers broad substrate scope and mild reaction conditions. The reaction consists of a Michael addition, 5-exo-dig carboannulation, and oxidation sequence under air.
G. Bharathiraja, G. Sathishkannan, T. Punniyamurthy, J. Org. Chem., 2016, 81, 2670-2674.
4-dimethylaminopyridine (DMAP) promotes an efficient and experimentally rapid protocol for the synthesis of 2,3-dicarboalkoxy-4-aroyl/heteroaroyl/alkanoyl thiophenes in high yields via 1-2 (C-S) and 3-4 (C-C) bond connections in only 3-5 min in DCM at room temperature. This method allows a clean and general synthesis of previously inaccessible and synthetically demanding thiophenes.
G. C. Nandi, S. Samai, M. S. Singh, J. Org. Chem., 2011, 76, 8009-8014.
A highly efficient amidation reaction of heterocycles with N-fluorobenzenesulfonimide (NFSI) presumably proceedes via C-H bond activation in the presence of cuprous iodide as catalyst. Various α-amidated heterocycle derivatives have been generated in good to excellent yields.
S. Wang, Z. Ni, X. Huang, J. Wang, Y. Pan, Org. Lett., 2014, 16, 5648-5651.
A TBAI/TBHP catalyst system enables a facile synthetis of highly functionalized 3-aminothiophenes from readily available allenes and thioamides in very good yields under mild reaction conditions via a tandem thio-Michael addition, oxidative annulation, and 1,2-sulfur migration pathway.
T. Han, Y. Wang, H.-L. Li, X. Luo, W.-P. Deng, J. Org. Chem., 2018, 83, 1538-1542.
An efficient one-pot procedure allows the synthesis of various functionalized 2-aminothiophene scaffolds catalyzed by L-proline in high yields under mild conditions. Low catalyst loading, simple procedure, and high yields are the important attributes of this methodology.
T. Wang, X.-G. Huang, J. Liu, B. Li, J.-J. Wu, K.-X. Chen, W.-L. Zhu, X.-Y. Xu, B.-B. Zeng, Synlett, 2010, 1351-1354.
A simple and highly efficient protodecarboxylation of various heteroaromatic carboxylic acids is catalyzed by Ag2CO3 and AcOH in DMSO. This methodology enables also a selective monoprotodecarboxylation of several aromatic dicarboxylic acids.
P. Lu, C. Sanchez, J. Cornella, I. Larrosa, Org. Lett., 2009, 11, 5710-5713.
Cross-coupling of aryl bromides with 2-thienyl, 3-thienyl, 2-pyridyl, and 3-pyridyl aluminum reagents in the presence of Pd(OAc)2 and (o-tolyl)3P provides useful biaryl building blocks. Additionally, the catalytic system was also suited well for the coupling reaction of benzyl halides with pyridyl aluminum reagents to afford a series of pyridylarylmethanes.
X. Chen, L. Zhou, Y. Li, T. Xie, S. Zhou, J. Org. Chem., 2014, 79, 230-239.
Conditions for the palladium-catalyzed direct arylation of a wide range of heterocycles with aryl bromides employ a stoichiometric ratio of both coupling partners, as well as a substoichiometric quantity of pivalic acid, which results in significantly faster reactions. An evaluation of the influence of the nature of the aryl halide has also been carried out.
B. Liégault, D. Lapointe, L. Caron, A. Vlassova, K. Fagnou, J. Org. Chem., 2009, 74, 1826-1834.
Thiophene was regioselectively deprotonated by treatment with Bu3MgLi in THF at room temperature. The lithium arylmagnesate formed was either trapped with electrophiles or cross-coupled in a ‘one-pot’ procedure with aryl halides under palladium catalysis.
O. Bayh, H. Awad, F. Mongin, C. Hoarau, F. Trécourt, G. Quéquiner, F. Marsais, F. Blanco, B. Abarca, R. Ballesteros, Tetrahedron, 2005, 61, 4779-4784.