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Totally Synthetic by Paul H. Docherty, 1 April 2006

Total Synthesis of Dictyostatin


G. W. O'Neil, A. J. Phillips, J. Am. Chem. Soc. 2006, 128, 5340-5341.

DOI: 10.1021/ja0609708

Showcasing their (silyloxy)enyne cyclisation (twice) in this neat synthesis, they used a Still-Gennari modification of the HWE reaction to complete the final macrocyclisation in 74%. However, it is their methodology that is most impressive: