Totally Synthetic by Paul H. Docherty, 19 April 2006
Total Synthesis of Dolastatin
I. Paterson, A. D. Findlay, G. J. Florence, Org. Lett. 2006, 8, 2131-2134.
Reassigning the structure of Dolastatin based upon his total synthesis of Callipeltoside, Paterson used two 1,4-syn boron aldol reactions to configure a considerable section of Dolatstatin, finishing the total synthesis in a neat 23-step campaign. The sugar-unit was derived directly from L-rhamnose, appending in moderate yield, but with impressive stereochemical control.