Totally Synthetic by Paul H. Docherty, 28 March 2006
Total Synthesis of Nodulisporic Acids D & F
A. B. Smith, III, A. H. Davulcu, L. Kürti, Org. Lett. 2006, 8, 1669-1672.
DOI: 10.1021/ol0602912A. B. Smith, III, A. H. Davulcu, L. Kürti, Org. Lett. 2006, 8, 1665-1668.
Two publications in Org. Lett. by Amos Smith this week on the Nodulisporic acids (D&F). Before you think this is all about building those quaternary carbon centres, they started with them built in!
No, these papers are about construction of the the indole system, building ring B to fuse with A and then constructing C, all in 7 steps. Very neat and powerful. So, in other words, good heterocycle lessons for those pharma interviews.